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59 2023-03-18
KºƬôӣKºƬôʹãt(y)ˎW(wng)ѼP(gun)KºƬf,KºƬr(ji),KºƬX,KºƬĹЧc,KºƬ÷cˎƷϢȫԃʹ
ƷQ:KºƬ
(zhn)̖(ho):ˎ(zhn)400013H12
:1.mίɄ(dng)}Ӳ(dng)}Ѫ˨]}סµԄ(dng)}]Y2.Ʒܸ֫wȱѪԝʹl(f)估gЪУί(Ѫܳg(sh)Ѫֲg(sh)(jng)гg(sh))a(b)ίԾYѭh(hun)ֲѪ܃(ni)Ѫ˨γɡ
÷:ڷһ50100mgһ2p߿ɸ(j)YҪr(sh)m(dng)ӄ
ͨQ
Ƭ
Σ
?1.mίɄ(dng)}Ӳ(dng)}Ѫ˨]}סµԄ(dng)}]Y
2.Ʒܸ֫wȱѪԝʹl(f)估gЪί(Ѫܳg(sh)Ѫֲg(sh)(jng)гg(sh))a(b)ίԾYѭh(hun)ֲѪ܃(ni)Ѫ˨γ
÷
ڷһ50100mgһ2p߿ɸ(j)YҪr(sh)m(dng)ӄ
(yng)
1.Ҫ(yng)^ʹ^ļµ(g)e߿ɳF(xin)Ѫƫߡ
2.Ξ鸹ÛIθmʹY
3.ٔ(sh)(yng)F(xin)ιܮlصֵ
4.żҊ^(yng)ƤW
5.żа(x)pƤ³ѪѪdzѪѪ۵׳ѪȈ(bo)
ɣ
ѪԼ(ѪѲë(x)ѪܴԼ(dng)ԝѪѪӌmԳѪȻѪA)
ע(xing)
1.Ⱥã
(1)ڷˎѷÿѪСˎ(簢˾ƥ֡ƥ);
(2)(yn)ظIܲȫ;
(3)Ї(yn)غϲY琺[;
(4)(x)p;
(5)^w|(zh)(du)Nˎ^^Լߡ
2.ƷѪˎg(yng)ӏ(qing)ԭпѪί
ɷݣ
ƷҪɷ֞
ЋDڋDŮˎ
PڋDŮӋ(j)/ċDŮ
ͯˎ
׃ˎİȫδ_
ˎã
ǰE1cƷf(xi)ͬӼ(x)(ni)h(hun)ն(qing)Ч
ˎã
1ѪС
1w⣨invitro
a.(du)СáȮ˵ѪСADPzԭϩIصȌ(do)µѪСۼ
b.(du)wѪСADPI،(do)µѪСһξۼ߀нxT(do)ӌ(do)µѪСۼK
2w(ni)invivo
a.ȮM(jn)пڷoˎԇ(yn)ADPzԭ(do)µѪСۼ
b.Ԅ(dng)}]Y߿ڷADPzԭϩIصȌ(do)µѪСۼ
c.woˎѸٮa(chn)ѪСۼBm(x)ҲɾSЧ(hu)p
d.ͣñƷʹƵѪСۼSƷѪˎȵ˥p֏(f)oˎǰֵδl(f)F(xin)зF(xin)ۼM(jn)
2Ѫ˨
o}Сw(ni)עADPzԭTl(f)ķ˨
ȮĹɄ(dng)}ע¹cTl(f)Ѫ˨֫ѭh(hun)ȫM(jn)չ
ƌȮĹɄ(dng)}ÓQ˹ѪܣTl(f)ľֲѪ˨˨Y
3ѪܔU(ku)
tKC1ǰF2a(do)µȮxwɄ(dng)}
ȮĹɄ(dng)}Ѫ
(du)Ԅ(dng)}]Yͨ^weӛ^쵽P(gun)(ji)cMѪ
M(jn)һͨ^^쵽֫ƤwضƤwѪ
4ÙC(j)
ƷƼѪС5-uɫጷӰѪС匦(du)5-uɫյĔzȡ(du)ѪСĻϩx]Ӱ푣ͨ^Ѫ˨A2(TXA2)ѪСۼ
Ʒͨ^ѪС弰Ѫƽ(ni)ĭh(hun)øĶl(f)]ѪСüѪܔU(ku)á